Pancreatic CSCs and microenvironment
نویسندگان
چکیده
منابع مشابه
Pancreatic CSCs and microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is the most common malignant neoplasm of the pancreas and presents with dismal prognosis. Key hallmarks of these tumors are chemo resistance and early metastasis, leaving few effective options for curative treatment. In part, treatment resistance might be spawned by tumor cell plasticity within pancreatic cancers, and specifically by therapy resistant pan...
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The diagnosis of pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis, in particular, when patients present with unresectable disease. While significant progress has been made in understanding the biology of PDAC, this knowledge has not translated into a clear clinical benefit and current chemotherapeutic strategies only offer a modest improvement in overall survival. Accordingly,...
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Accumulating evidence has shown that cancer stem cells (CSCs) have a tumour-initiating capacity and play crucial roles in tumour metastasis, relapse and chemo/radio-resistance. As tumour propagation initiators, CSCs are considered to be promising targets for obtaining a better therapeutic outcome. Cervical carcinoma is the most common gynaecological malignancy and has a high cancer mortality ra...
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Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8+ T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the clinical evaluation of immune checkpoint inhibition as a pancreatic cancer therapeutic strategy.
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Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the USA, accounting for ~40,000 deaths annually. The dismal prognosis for PDAC is largely due to its late diagnosis. Currently, the most sensitive diagnosis of PDAC requires invasive procedures, such as endoscopic ultrasonography, which has inherent risks and accuracy that is highly operator dependent. Here w...
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ژورنال
عنوان ژورنال: Genes & Cancer
سال: 2015
ISSN: 1947-6027
DOI: 10.18632/genesandcancer.80